Reynald and his pirates.

You do know that Mecca was beseiged by the Ummayad Caliph Yazid I in 683 and I think the Kaba was even hit by a catapult (interestingly enough, Muslim jurists or the middle ages debated on whether using a catapult was allowed, which may have had something to do with the issue of killing women and children, but this would also be on their minds I would guess).

As if that wasn't enough, the Fatimids (who are Ismaili and considered non-Muslim by most Muslims) sacked the city around 930.

One last time was the Wahhabi uprising against the Ottomans in 1803.

-Yazid I besieged mecca for some months and shot the kaaba with the catapault in 683 AD.

-Al-Hajaj ibn Yusuf under Caliph AbdulMalik's command (debatable point), besieged mecca in 692 for a couple of months, and again, shot the kaaba with the catapult.

-In 930 AD, the Qaramita, aka Carmathians, an Ismaili sect from eastern Arabia, sacked mecca and the Haram, killing all those inside it, and blogging up the well of Zamzam with the severed heads of the pilgrims, and set fires all throughout the Haram. They also looted the black stone, and sent it to their capital of Al-Hasa in north eastern arabia; thinking it was the 'magnet' behind attracting pilgrims to that holy place, and by placing it in Al-Hasa, people will get attracted to that city and it shall flourish. This did not have the intended effect, and the pilgrimage continued uninterrupted.

-In 1803, the Wahhabi forces under Saud ibn Abdulaziz ibn Muhammad Al-Saud, took mecca, however, they took it by piece, without shedding any blood, respecting the holy sanctuary. However, they did destroy the graves and tombs of the important people there, whom people started to worship as demi-gods, returning the holy sanctuary to its orthodox islamic protocol. Which, as I see it, the right thing to do.

-In 1925, Saudi forces of the third saudi state capture mecca, peacefully, without bloodshed, under the command of Prince (later king) Faisal ibn AbdulAziz. On the 10th of January 1926, King AbdulAziz ibn Saud Al-Faisal was called King of the Hejaz, by the meccan clergy, and thus, ruler of mecca.

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Oh, and BTW, no bloodshed was permitted in mecca, even pre-islam.