Stupid Aedui is expanding too much. I was happily taking over Iberia at my own pace, when the Aedui became the most advanced faction. Then, I notice just how big they've gotten and a year or two later, they attacked. Annoying, but I can probably defend most of my Iberian holdings.

Other than that, it's surprising how intact the east is. It's 226, and both AS and Ptolemies are still powerful, although, Antioch has recently fallen to the Ptolemies, and that's usually the turning point. I'm not sure how that Indian city turned Parthian. Does it rebel to them?

Also, Ankyra went to the Aedui, which doesn't happen too often.