Having KH and Baktria is already pushing it. If the game started earlier then they would probably have to be removed. In 280, the Antigonids were not a power either and Makedonia was in disorder without a leader. The Galatians were still in the process of settling in Galatia. The Romans were much weaker and controlled little.
272 is a good year because KH and Baktria can kind of be streched to fit in and yet Epeiros is still a power. During and just after the start date the Romans begin their true rise to power with the consolidation of southern Italy. And there is a Syrian War in progress that has divided the Hellenic and Hellenistic world.
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