Lots of great options, I'm interested to see what others use.
Here's my list for Firefox 3 (that haven't been mentioned already):
PicLens - very slick interface to picture archives
Web Developer - great coverage of the entire web coding arena
IE Tab - switches page view to and from the IE engine
Flashblock - the best addon ever
Forecastfox - handy, nicely configurable weather
Firefox 2 addons I really, really miss and still use FF2 for:
Firebug - step through JavaScript, invaluable
Fire FTP - full FTP client in a browser window
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