If I remember rightly running/opening a file essentially saves it to a temporary area (which automatically wipes itself clean periodically) and then runs it. Saving a file allows the user to place it in more permanent location and then run it. There is little difference between the two options, so saving it most likely won't yield any different results.
Might I asked what happened when you did open the file - did it appear to install the drivers or did nothing happen upon opening it?
If it didn't work as you would expect it to, you may wish to try downloading and installing the package again.
If it appeared to work OK, then the chances are that the problem wasn't related to the graphics card driver. You could try downloading and installing again, but I'm uncertain as to whether that would be useful in this case.
Might I ask if the problem has affected any other games? If it has then it may be a physical problem with your graphics card itself. If it hasn't then I can't really think of a further cause. You may wish to ask Mithrandir to move the thread to the Apothecary for you - the folks over there may be able to provide a more advanced set of possible solutions.
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