I've played every game mentioned here except the Witcher (waiting for the free upgrade pack) and the Gothic series (started Gothic II gold now), and can recommend any and all of them without qualms.

The fallout duo are good games and well worth playing, however there's a word of warning which I feel needs to be given with them and seldom is. They don't always get along with modern hardware. I tried to play these a bit ago and found myself plagued with issues. The screen kept going completely black every couple of minutes, meaning I had to scroll around to force it to re-draw the graphics and restore my view. The game crashed repeatedly, and eventually it crashed and corrupted my savegames. I couldn't complete either. If you've still got your old PC try to play them on that instead.

To join the Anacronox reminiscence, Anacronox was an awesome game. Pig ugly even back in ye day, and sporting what was once a rare art styling in games (westernised manga) it shone in every other area.

What other RPG lets you have a grouchy old man with a huge beard and a walking stick on your battle line up? Grumpus was a permanent fixture on my team, and he yammered his way past many obstacles. Does anyone remember what the world (yes, world, as in an entire planet plus population) which joined your party was called? It’s been so long since I played it …

The other main aspect I remember Anacronox for so fondly was a certain BIG surprise in the plot.