Infrastructure-wise I'd suggest putting a satrapeia philhellenike (L3 gov) in Ipsos and Nikaia, and then build up the regional mics up to level 4. this will give you access in Nikaia to hoplitai, keltohellinikoi hoplitai, thraikioi peltastai and thraikioi prodromoi which are all great troops. In Ipsos you'll get access to Klerouchoi phalangitai to replace your levy phalangites.
The mine in Nikaia bring in 1200 mnai/turn for the first level, which is a nice boost.
I also like to conquer the two bosporan towns for the increase in sea trade.