Got my ass beaten by the Seleucids and the Ptolemaioi once they formed an alliance (first and only time this ever occured between those two) and suddenly started sending out army over army in every direction (I had secured northern Asia Minor by that time while the Ptolemaioi managed to occupy southern Asia Minor from the AS before they formed an alliance...soon afterwards, I was REALLY diminished and yeah, I played this one to the bitter end which came shortly after. But I wasn't the only one steamrolled by the super-alliance, Hayasdan and Baktria fell even before I did and both of them were slashing their way through their bordering Eleutheroi cities...was one of the craziest game I had....

Also once I lost with Pahlava when I got engaged from all sides, Sauromatae from the North (who always advance VERY quickly), the Saka Rauka from north-east, Baktria from the East and the Arche from the south...no way to stand against them, even with your super cavalry...