Give Asia Minor to Seleukids and fortify Byzantion... REALLY fortify Byzantion. It works the other way around - as Seleukid a fortified Byzantion can keep all the European powers at bay for the ENTIRE GAME if you just fill it up with good phalanxes. I don't know what kinda troops you Romans have, but just get a lot of good defensive ones and hold it no matter what. I don't think AI's in Asia Minor will enter Greece without taking Byzantion first. They won't the other way around at least (my Pergamum is barely garrisoned while the Macs are tearing themselves to shreds against Byzantion).
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