I’ll need to get a feel for the possibilities first…but as India, North America, and the Caribbean Islands can have land units, and as I understand it , Africa is a trade theater I will likely want to play with sending troops and worry about Africa when I have spare ships.
Why would Africa be a trade theatre? Only the southern portion is cut off, you get the whole northern half...

Anyways, for myself, I'll insignificantly plant my little flag here and there. My main concern will be playing around with European politics and allying with various native nations to keep the European scourge off their lands(exception made for myself, of course).

Also, once I get down to playing as a Native American faction, I'll be colonizing Scotland!