Pyrrhos: his son and daughters married?

**desert** · 11-19-2008, 01:45

Really, continuous inbreeding is what causes all the deformed babies and the like.

For example, consider Disease a. It is, say, autosomal recessive like cystic fibrosis. This means that, if A is the normal version of the gene, and a is the messed-up version, you would need aa for the symptoms to manifest. So say that the messed-up allele "a" is common in a family, and two members of the family, one of whom is affected (Aa), and the other wildtype (normal) AA mate.. The cross would look something like this:

AA x Aa =

| Aa | Aa |
|----- |------|
| Aa | Aa |

So all of the offspring would be carriers, but none would exhibit symptoms of the disease. NOW...
say two of those kids also mate one day. That would look like:

Aa x Aa

So basically 1/4 AA, 1/2 Aa, and 1/4 aa, meaning 25% of the kids will now have the disease. Continual inbreeding, lets say the aa x Aa would lead to 50% having the disease. Eventually, almost everyone might have the disease.

Presumably this is a rare genetic disorder, and so if the original parents(AA x Aa) had mated with individuals outside of their own family, they would have most likely mated with someone who was AA, leading to a much smaller probability of a descendant having the disease.

Bleh.

**Maion Maroneios** · 11-19-2008, 10:24

That's correct, though not all diseases are transffered to offsprings with two genes. Sometimes the genes are of another type (don't know the english terms), like the ones that have to do with someone's blood type. In that case, you've got I(a) for A blood type, I(b) for B blood type and i for 0 blood type.

Maion

**Celtic_Punk** · 11-19-2008, 14:33

thats a headache and a half *slams head on desk several times* good thing im a hobby historian and not a scientist.

**Maion Maroneios** · 11-19-2008, 15:21

Well, I like history too while at the same time I am a Physics student. Don't see anything wrong with that.

Maion

**Celtic_Punk** · 11-19-2008, 15:23

Oh you misunderstood my joke, I was just merely saying what a headache being a scientist would be for me lol

**Maion Maroneios** · 11-19-2008, 15:25

Yeah, I got it but I wanted to sound like a serious scientist :-P

Maion

**gamegeek2** · 11-19-2008, 21:06

Well, I'm just chilling in high school. Play EB, AOE, AOM, M2TW (sometimes), Battlefront 2.

I hope I have time for the forums when the real work comes around

**desert** · 11-19-2008, 23:00

Yeah, I was just trying to give a simple example, Maion.

And the blood type thing is actually called codominance; I haven't learned of any codominant genetic disorders though, and would (probably) only ever hear of them if I decided to pursue a career in genetics research or something similar.

**Maion Maroneios** · 11-20-2008, 08:40

Originally Posted by desert

Yeah, I was just trying to give a simple example, Maion.

And the blood type thing is actually called codominance; I haven't learned of any codominant genetic disorders though, and would (probably) only ever hear of them if I decided to pursue a career in genetics research or something similar.

Ah, thank you for pointing that out. Well, we where taught some genetics at high school, but the fact that Biology is so damn boring and theoretical (in Greece we don't do any labs at all) made it one of my least favorite subjects. Hence I am studying Physics and not Biology!

Maion