One last thing. For best results set it up using Windows task scheduler to run once a week or once a night. That way you don't have to worry about doing it manually all the time.
Edit - So I just realized that my box hasn't been running the weekly defrag for the past 6 months or so.My drive was about 50% fragmented with about 60% total space used. It took about 3 hours to complete the whole operation, and I have a fast SATA HDD.
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