They outgunned anything they couldn't outrun, for the most part (one of them, the United States, was a total lemon of a sailer).
They could, indeed, have fought a British 64 with a good likelihood of success, but please recall that the British were phasing that class out themselves at the time -- they were aware of its limitations in the Napoleonic era.
The USN's "44's" ran from British "64's" anyway, despite having a weight of metal that might have let them win -- it would have been a horrifically tough fight and possibly Pyrhhic.
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