1. It really depends on your long term plans for the Middle East, and who you're at war with. For example, if you're currently fighting the Egyptians, I'd recommend taking Acre next to give you a firm front against any Egyptian armies coming from the Nile Delta. If you're fighting the Turks, Adana will probably be the best way to go. If the Mongol horde is threatening to attack, then Aleppo is probably the best choice. It goes without saying that you must first pacify Antioch using the old sack+priest spam.
2. In my opinion, Vienna a very tempting target. It makes plenty of money (especially for an inland city). It may stretch your forces a bit, but if the Germans are already reeling from your previous offensives, it won't get much easier to grab a highly profitable province. Secondly, Vienna is pretty easy to defend thanks to Danube river. Any offensive from the North or East must cross the river, giving you an easily defended border, and the province is quite large to the South, giving you an early warning system. Finally being France, I'm assuming that you've already taken Innsbruck and Nuremberg, so the West shouldn't be a problem.
Prague is a bit of a different story, since it lacks the silver mines of Vienna. Economically, it isn't very strong, and it is harder to defend than Vienna. That being said, as a Rebel, one of the other factions will eventually take control of it. Strategically, it is probably best to just leave it as a buffer zone between you and Poland, but if I were playing, I'd probably take it since I'm almost hyper aggressive against Rebels.
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