i store all my data in a truecrypt container file on a separate partition on my gaming PC, which i back-up by copying to an external drive, and then back-up again by copying from the external to my media PC downstairs.
I have 32GB for Vista + Drivers on C:\, and put My Documents + Apps on a second 32GB partition, and then have 128GB for Games.
the truecrypt container occupies a separate terabyte drive.
it works for me.
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