1) He could have married at least. Yet, with a mother like Theophano...
2) He could have forced his neices to marry on time. Both Theodora and Zoe (the heiresses to the throne) were left unmarried. A capable husband might have secured the future of the dynasty. A strong dynasty with a capable leader was essential for the surviving of the Empire (with few exceptions). Instead sterile and old rulers, both men and women, followed one after another.
Basil II was indeed very capable as general and a politician but I think he underestimated the importance of strong bloodline.
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Isaac Comnenus was indeed a good choice. As far as I can remember, he had problems with the dynatoi (strong centralism policy) and the capital administration. Yet, his bad health contributed a lot to his failure.
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