Any problems between major updates are usually fixed by a clean reinstall - and anything a reinstall doesn't fix can be fixed by deleting your user profile, plugins etc, this is usually in ~/.mozilla/firefox/ or usually "C:\Documents and Settings\your user\Application Data\Mozilla" for windows users. It means you'll have to re-do all of your customisations of course.
-Edit: Any problems with specific websites are usually cured by clearing the cache.
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