Yes it looks like the hard disk drive simply failed. The symptoms of the boot agent loading and the non responsiveness, hourglass etc all point to this being the case.
And so your problems began again once the secondary HDD was reconncted? I wonder do you have enough power supply wattage to run that lot?
I doubt it's the game - that's probably coincidence. Have you updated all drivers for motherboard chipset, graphics card, sound and ethernet/LAN?
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