That's an interesting analysis, especially the correlation between the fall of Constantinople and the "beginning of the end" for Genoese/Venetian power. However, I have to question a couple of things:
1 Why the Ottomans would have cut trade off any more so than the Byzantines? As you said, trade was more of a constant reality than a negotiable and infrequent fancy. The Venetians traded extensivley with the Ottomans, it was their continued wealth and influence in the eastern mediterranean that eventualy lead to conflcits between Ottoman and Venetian. Furthermore, trade with the east depended as much on the states in between Asia minor and China/India as those at the extremities of the caravans. If continental overland trade was risky or obstructed, it was surely as likely to have been so due to situations in Persia, Afghanistan etc?
2 Wasn't there enough going on in Italy which had a more immediate effect? i.e. Spanish control of the peninsula -absorbtion of Genoa into the Spanish sphere of influence and economy? The vast majority of Spain's New World ventures were financed by non-Iberian bankers/traders, eg Genoese, other Italian, Flemish, Dutch, German. Especially the Genoese.
Ultimately, Yaseikhaan is right that the strategic worth of Constantinople/Istanbul was compromised by the Western european powers seizing the economic initiative and trading directly in Asia, as well as acquiring New world wealth. So really, it's the Portugese, Dutch and Spanish who sabotaged either occupier of Constantinople/Istanbul's hopes of trade derived wealth.
In fact, for the agrandized Ottoman empire, the strategic focus of trade switched to that passing along the Arabian coast, as the Portuguese held island forts off Yemen and Oman. I think there was even an abortive attempt by the Ottomans to invade India at one stage -to secure control of resources at their source.
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