I don't like taking Antioch too early, because losing that city really cripples Seleucia and makes them very vulnerable to the Pahlava.

As the Ptolemies, I'd rather fight the Seleucids than the Pahlava, that's for sure! So I don't want a total Seleucid collapse.

In the early days of a Ptolemaic campaign, I prefer to settle for taking just Damascus from Seleucia, while going after Eleutheroi cities in Egypt, Libya, Sinai Palestine, and Asia Minor, and building up my economy.

As with all factions I play apart from Pahlava, Eleutheroi are my priority targets.