Even in the cases where foreign based culture ruled larger population of natives and were themselves in turn conquered it wouldn't be surprising that the first rebellion was led by a member of the former ruling caste unless a total purge was done... but that is difficult as often the former rulers intermarried with the locals and the former 'foreign' systems seem more familiar to the people who are rebelling than the new imposed ideas of the latest rulers.
So the example if Ptolemaioi were conquered by Rome... then a core region revolts- that chances that it is a totally Egyptian revolt without any Ptolemaioi influences seem very slim. With Seleukia and other descendents of Alexander's empire its more difficult because which regions should count as "core" and most of the culture had some influences from language and culture from Alexander but after 100 years of foreign rule (non-Greek) and then a revolt... would Seleukia really be restored? In that case it seems questionable but that makes it more a matter of time than potential and since the timeline is relatively short for EB2 and the time from when Ptolemaioi or Seleukia might be conquered to the end is even shorter so I don't see why not.
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