No problems at all getting the game up and running, though I was playing GTA IV last week, and I think the tweaks I had to do to get that running properly have meant I didn't have to go through them for LA Noire. Gameplay wise, it's absolutely fine. Controls a bit clunky in certain areas, but no worse than I would expect for a game of this type on PC. I quickly played through the Patrol desk just to check it out, didn't come across any problems, no crashes, lag, graphical glitches, nothing. I would recommend it on PC to anyone who was on the fence.
edit: My system for reference;
64bit Windows 7
Intel QuadCore Q8300 2.50Ghz
4 gig Ram
Geforce 9500 GT
Not a great rig, so it should run well on any up to date system.
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