Exactly - we aren't always going to know a priori whether something we say is offensive. There are always grey areas and differences of opinion and we should not be afraid to express ourselves naturally because that is the life blood of a discussion forum. The important thing is to be responsive to feedback and learn from our interactions with those from different cultures.
For example, while travelling in South East Asia a left-handed travelling companion of mine was made aware that he should not use his left hand for picking up food. Why? Because in that culture the left hand is used for cleaning ones private parts after using the toilet.
He could have obstinately stuck to his guns and said "well I'm left handed and I'm not from this culture so I'm not going to change (and by the way I don't use my hand for that)" but instead he was responsive to feedback and respectful of the culture he was interacting with and had a much better travel experience (I'm sure!) as a result.
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