Where should I go to as my next holiday trip?

[Moros]

So I've got four options: Athens, Rome, Prague and Budapest. Which are definitely worth it? What are the pro's or cons. Anything else I should know before going.
Note I've been in Rome before but only for a single day or something (don't remember well actually). Also how is Athens are there still a lot of strikes or other stuff going on there due to the crisis that could negatively influence a possible trip?

Thanks in Advance!