As much as I loved the initial SP balance, it gets really skewered once you unlock some of the better weapons. I was playing on Insanity like it was absolutely nothing before news of the retcon DLC became known. Its really surprising, since Insanity in ME1 and ME2 were pretty frustrating, here its almost trivial. All you have to do is buy one or two weapon upgrades and suddenly the power weapons cannot be stopped.
The M-37 Falcon is the most heinous example of an OP gun: rapid fire grenades turn Brutes into mulch. This is likely the reason its fire rate got nerfed pretty significantly in MP.
The Grail Spike Thrower (one of my favorite weapons) is unfortunately also pretty overpowered. I can headshot anything, instantly, from any range with this beast. Its hilariously good fun, but also too easy. I think I might completely wipe my save and just start again from whatever level i imported in from ME2. Wiping out entire hallways in an instant on Insanity just doesn't feel right.

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