I can't believe anybody would want anything from that steaming pile they call Rome 2 in EB2...
I doubt this idea would work though. AI in Medieval 2 Total War isn't very sophisticated on the campaign map. Allies and vassals will declare war on you at random, usually one turn after the alliance/vassalage was made, so the Seleucid satrapy would be at war with the Seleucids as soon as you hit end turn at the start of the game.
Also I wouldn't avoid playing the Seleukids just because they're huge, in EB1 this was handled really well. You were by far the biggest nation in the game and the largest army and the richest... but only on the first turn. On turn number 2 you had rebellions in your eastern provinces, you were getting hammered by the Parthians, your army was large but spread all over the place, you border some very powerful nations like Ptolemies and Pahlava... and Pahlava are very annoying to fight with all those horse archers. So you never felt like a superpower right at the start, that took lots of time to achieve.
Also the Seleucids are one of the most fascinating people to play as. So many different provinces and unit and building descriptions to read... they're amazing.
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