Yes, they use cruise missiles and there are systems to defend against them.
Sarmatian is probably correct in that they're not fool-proof, but I'd think they can take down a few before they reach their target. Might also depend on the terrain and other factors. These systems even have a name:
https://en.wikipedia.org/wiki/Close-in_weapon_system
Depending on the size of the cruise missile, the flight path, terrain, etc., it's also possible that airplanes can intercept them.
Of course one question might just be how much gear capable of doing this does Russia have close to the target in the first place?
Even mortar and artillery shells can be targeted by some modern systems:
https://en.wikipedia.org/wiki/Counte...ry,_and_Mortar
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