As far as I remember, no, not on turn 16, but the game has crashed a few times clearly due to memory leak bug. In my current third campaign I had that Ankyra battle issue on turn 4 or so - after reloading the save I auto-won the battle per console.
This is also now my third clean installation of the mod (I even downloaded the patch and animations file anew) and apart from memory leak bugs and that battle crash, it's been stable so far. In all my three games however there had been no colonists on turn 17. I quit the first and second game on turn 20-21 because of that, but then continued the third up to turn 39 at the moment.
As I always spended the initial settlers on building settler towns in Antiocheia, I also wondered if building them in the very same town the metropolis is in could have had that effect, but this is purely guessing. It just seems non-coincidental to me when settlers arrive precisely after the double amount of time as expected.
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