The best setting is the best your graphics card/system can run.
Personally i would rather use a higher Res than something like 4xAA but that again would depend on your system/monitor.
If the features were present in the game options i would set all the settings for my graphic card to 'Application pref' or 'Performance' and tailor your graphics settings via the game menu.

I dont have the game yet (UK) but i plan to run the game in 1600x1200 though if the text is too small i might reduce it ot 1280x and mess around with my quality settings to find the look i'am happy with though i have a feeling that AA will be unecessary on a game which from the demo appears to be viewed from a distance most of the time.