Don't forget about GCS. They broke their alliance with me maybe 10-15 turns after Pontus did. I only now have a friendly neighbor because Thrace is invading Pontus... Which helped me out quite a bit...
I wonder what Seleucia did to its neighbors to piss them off before I gained control of the empire.
Edit:
Hah, Thrace just sailed around and attacked one of my lightly defended cities. So much for having a friendly neighbor...
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