Personally, it's Unit detail. When I put it to "very high", the game slows down. On "high" everything is manageable.
Kraellin says AA too, so I keep it down to 2x. Actually, I had it to 4x not realizing it was the Unit detail that is making the game drag.
Have you updated your drivers btw?
I only use 1024x768 since I don't know how to mod the auto optimisation file to 1280x800. I'd say start with the unit detail then the resolution (but since your unit detail is already "high", start with the resolution). I'm surprised your machine is slowing down so easily.
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