This happens around the 13th year of game play and on my recent roman campaign I have never seen it worse. Every city on the Greek Peninsula was at less than 700 for their population and still dropping. I had 6 cities on Greece at the time and lost them all because every army I sent to retake the city contracted the plague and died, but some how the macedonian armies were unaffected even though their cities were breaking apart.
In the end the Senate did nothing but tell me to retake the cities, which were at 500 population and couldnt build anything else, and when retaken caused my troops to die from the plague in addition to their generals... It wasn't worth it. I made a new game.
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