The only problems that I can see with the hub defence strategy are the following:
1. Upsets to unit production (specifically units like cannons, ships etc, that take 3 years. These revert back to zero if the province is removed from your control.)
2. Upsets to building construction (19/20 years completed for a citadel. Suddenly you are attacked and the province removed from your control... BAM!! Back to zero, mate.)
3. Retaking mountainous or river provinces the following turn.
4. Reassigning governorship (more an annoyance than anything)...
Apart from that, it's a highly economical way of guarding one's borders.
I personally use a combination of cheap unit spam (as a numbers deterrent) for frontier provinces, and miniscule garrisons + bawdyhouse spies for provinces that are "internal" within the empire.
This has worked really well for HRE because of the geography of the Empire...
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