I have had two non-duplicable CTDs.

I've had only one persistent CTD, which was caused by AI army movement. I was able to use Control [Faction] to "fix" it, so I didn't tick your second option. It would've been campaign ending if I didn't read Sim's "What to do with a persistent crash" thread on the other forum.

I'm playing as Baktria and have got to about 258BC so far.