I started a Carthage campaign in 1.0. It was clear sailing for the first ten years or so. When I resumed it in 1.5, the Romans got MUCH more aggressive. They were attacking me on every side, causing a real headache until I got clear naval supremacy. The Julii also bribed away my top troop-producing cities and several family members. I found it much harder, post 1.5.
Edit: I actually ended up losing this campaign last night; I forgot I had set it initially to the short campaign and basically ignored the Spanish, wiping the Romans off the Italian peninsula instead. The Egyptians won, to my shock. Had I been concentrating on the Spanish after I killed the Scipii (20 years ago) there would have been no problem, but, uh, I forgot.
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