Mm..little more info might be helpful. What are your system specs?
If it ctd's even with a supported graphics card and you have the latest drivers, the problem is probably not graphics card related.

I can think of a couple things off the top of my head, but I'd like to know a couple things. What are your system specs, have you tried to uninstall then re-install the game (the computer could have possibly screwed something up during the first install process accidentally), do you have windows xp service pack 2, and are you trying to run it with mods already installed or is it a clean version?