Another, rather obvious way to get rid of this nightmare is attacking and destroying the Papacy militarily. They will reemerge, but if you left Rome and the Papal States nicely burned (as should be done by any self-respecting christian), they'll be powerless for a while (leave the Italians as buffer if possible). Also, in being destroyed, they will lose all strategic units, including inquisitors. With Rome burned, this means that yonder reliquary that's been giving you so much trouble has been destroyed, too. Having masses of troops to support (the AI never disbands troops) and lands totally bare of infrastructure, the Papacy can't hope to build up anytime soon.
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