Reading all the opinions regarding inquisitors, I think it rather boils down to the time of day when you installed the game and the start chard being in your favour.

I only had problems with the inquisitors in my first game when I didn't pay attention to religion, priests or relations with the Papal States. Then they were all over me. I also played quite aggressively against other factions and the pope wasn't all that pleased with me. (dif: med; faction: Britons)

Now I try to get the papal states as my allies as soon as possible, give them trinkets and gifts and try to keep 'em happy. I also have all the priests available and keep upgrading the churches. I'm beginning to miss the suspense of seeing an inquisitor. Well, ok I saw one hanging around in Livonia where two of my priests were training, and even though the inquisitor was near them, it didn't even hold a trial. (dif: hard, faction: Scotland).

I also have a VH camp as Spain, the catholicism percentage sucks in my provinces (75-90% with the average of 80%) but my relations with the Papal States are v.good or perfect and no inquisitors.

Then again I've read about players who pay a lot of attention to religion but are still burdened by the inquisitors.

Is it another roll of the dice at the beginning of the campaign which defines whether you have to deal with inquisitors or not?