Quote Originally Posted by Musashi
It always seems like people who've never actually swung a two handed weapon think that you turn into a lumbering sloth the moment you have one in your hands. The actual truth is that the difference in time between slashing with a greatsword and slashing with a dagger is maybe a few microseconds. It's mostly a matter of how fast you can swing your arms... The weight of the weapon is nearly irrelevant unless you're trying to use something that is literally too heavy for you to lift and swing.
Speaking of weight, try playing TES: Oblivion and getting your hands on 48lb Dremora Longswords... that's almost as much as some suits of plate armor.