For me, you should get Antwerp, near British Isles. It controls all the trade near Scandinavia.
For the West Mediterrenean, your priority should be Genoa and Marseille, as these two cities mostly operate the trade there. Then you can think of getting Ajaccio and Cagliari. If you develop these cities, they can turn out monster-trade cities. Then you can get Florence, Rome, Toulouse and Palermo, but these cities are not much important as others.
For East Mediterrenean, I'm not very good at it. You MUST get Venice, I got 50.000 from sacking it and it gives me 4500 florins by turnYou can get Jerusalem, Acre, Nicosia, as they seem to have lots of trade routes.
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