Quote Originally Posted by Kavhan Isbul
Or, and this is more advanaced now, you can send your best 2 assassins after the Pope and hope that they will manage to cause his untimely death.
Good call. I've just never managed to get assasins trained up to the point where they can manage to kill kings or popes. After I've trained them up on diplomats and princesses (and even each other) I generally just use them to kill rival inquisitors in my own provinces, as assasins are the only active defensive measure you can take against them.