Quote Originally Posted by TinCow
Personally, I think it would be best to use an Infinity Engine style hybrid, where it's turn based, but runs in real time and you can pause to give commands.
There have been a few good debates about this. My two cents, I wouldn't be opposed to it at all, IF it's done and implemented right. The issue is that it tends to break parts of the SPECIAL combat system, sequence being one of these things off the top of my head.