Diaspora, within the next millenium.
We are too close -- in generations of techonology -- to constant boost capability and reliable enclosed remote environments.
Add in population pressure as an incentive....
Actually, the development of a reliable fusion engine to power a constant boost ship would make the entirety of the solar system available for use in short order. It would be my candidate for a "Manhattan" style project.
With constant boost ships, trips between stars become arduous and extremely costly (as opposed to flights of pure fancy).
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