Regicide

[Bob the Insane]

Regicide missions are the only really difficult missions in the game... Anyway, they are only worth it if you're after the money because palying on Hard setting, I've yet to notice the improvement in the relationships with the asking faction.

Yeah, it would be more worth the effort if it gave a ceasefire as well as the improvment in relations.

Assassins may be put to better use than getting killed trying to eliminate a faction leader (if you can spare the bonus cash...)

Agreed, a maxed out assassin can cut through your opponent's agents and junior faction members like a hot knife through butter...