I say nay. Copy protection is only annoyance for honest customers and no problem for pirates. Sometimes it even can be major annoyance for honest customers and still no problem for pirates. It won't even stop casual copying, because all those cracks are available on net.

With programs its not even like in war, you build walls to get it more costly to conquer your lands, because theres no cost on other side. Most people just crack games for fun. Its like youre building a fine wall that cracker will crush with his hammer and have fun with it. I just can't see reason in copy protections.