Be careful of how many agents you have; they cost upkeep too.
Disband as many militia within your cities that are deep in your territory. Try to only keep those with free upkeep.
Adjust you capital as necessary to minimize corruption.
NEVER NEVER build the brothel line of buildings because your governors will get horrible traits and you'll have to end up killing them all.
Send a couple of merchants near Constantinople for the silk relatively quickly. Good merchants can make a couple hundred gold on one easily and get much more from taking over nearby merchants
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