When it comes to X-linked genetic disorders that are often or always fatal at early ages, inbreeding is not much of an issue, since the males are culled. When it comes to autosomal recessive genetic disorders though, inbreeding is highly relevant. So go write a book about the "Austrian lip" disorder that struck the house of Habsburg.
You may want to check this out:
http://en.wikipedia.org/wiki/Haemoph...ropean_royalty
All the inheritance of the hemophilia A allelle in the European royal families was through the women. Most of the male children who received the allelle died at early ages (though some did indeed survive into adulthood).
The Russian royal family inherited the disorder through Princess Alix of Hesse and by Rhine. Thus inbreeding was never involved.
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