The Greeks Expanding east isn't too rare in my campaigns - they use their "outpost" city of Pergamon in Asia Minor to take over their fraction of the crumbling Seleucid Empire. Once they've finished fighting the Seleucids they typically end up grabbing a small amount of the other factions in the area (Armenia and Pontus). Although they usually do well up to that point with no "uber" factions (Egypt or the Romans) in their way of this expansion, their lands always end up colliding with Egypt which generally means out and out war between the two.
This is always the bit where the Greeks usually start to suffer. Although they are relatively powerful, and still have a large volume of land, Egypt is always bigger, better and richer. I've seen the Greeks make a little headway into Egyptian lands, but they always get dramatically pushed backwards towards their starting regions. Quite simply it ends up been one region forward and then two regions back.
Once though I did have an exception to this rule. The Greeks had expanded East as usual, and were actually in a sort of "deadlock" with Egypt. In this case though, the land balance between them was broken by my Scipii invasion, so I couldn't really consider what happened next, a divide of that area between me and Egypt, accurate.
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