Website from picture

[Mithrandir]

I've designed a site in Photoshop something like below,


So basicly I want the site to look exactly like that, but with Iframes and links.
where I want 1,2,3 to be links to change the big Iframe, how can I accomplish to get the links and the Iframes where I want them? it's a positioning question I guess...

edit: I know HTML, and know of CSS (but can't write it myself). So it shouldn't be too difficult or I get lost.