Conquer Ptolemies.
Consolidate eastern territories/subjugate Baktria/Pahlava/India.
Conquer/subjugate the whole of Anatolia, everything south of Caucasus mountains, and possible Arabia.
Conquer the "Homeland", ie Makedonia/Hellas.
Focus on consolidating borders, build up trade, diplomatic relations and infrastructure.
Be
the world power for a few centuries, defeating a few (nomad, in this case) migrations.
Have a civil war or two.
Have your economy start to weaken and your currency lose values, partly because of using less valuable materials to mint them (in order to have more money made to fund your empire's undertakings).
Have another migration, which you struggle with defeating, and perhaps a civil war with a similar scenario, too (at least either one of them).
Have some parts of your empire do better than others, leading to growing dissatisfaction in the general populace of your empire.
Have your empire split into several parts, ruled by your sons, to able them to be better defended...
Edit: Oh, and I don't know nothing, just some speculation based on very little amount of actual information. 8D
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